Poor Fluttershy has a soft heart and clearly the tragic tale of Dom Santiago touched it deeply.
I hadn't seen this one yet and felt it just.
I also figured GOW3 has been out long enough for this to be less of a spoiler and more an amusing throwback.
To be honest I found this scene in the game rather devastating too
Meme (c) Borrowed from Know Your Meme
Fluttershy (c) *fyre-flye and Hasbro
Gears of War 3 (c) Epic Games and Microsoft Studios